Shiitake mushrooms more,
Sealing wax mushrooms more,
Woolly ink mushrooms more.
+ AHCC extract
+ Flavin7 Bioflavonoid complex
– AHCC (Active Hexose Correlated Compound), a combined active hexose compound is a chemical obtained from the yeast cell wall of the shiitake (Lentinellus edodes) fungus and other fungi fermented on rice bran.
– Developed for the treatment of lifestyle diseases. Developed by Toshihiko Okamoto, a professor of pharmacology at Tokyo University, in collaboration with Amino Up Chemical Co. in Sapporo, Japan.
Why is AHCC more effective?
– In their natural state, the substances of medicinal fungi are less able to be absorbed. Their biologically active ingredients, polysaccharides, are too large to easily pass through the miniature gaps of the gastrointestinal tract.
– Due to its low molecular weight, acetylated alpha-glucan is more easily absorbed compared to higher molecular weight beta-glucan.
– The acetylated alpha-glucan, unique in AHCC, is formed during the cultivation of fungal mycelium. Glucans are polysaccharides that have an immunostimulatory effect.
Developed to treat lifestyle diseases:
– AHCC was first used to reduce high blood pressure, and then researchers at the University of Tokyo found that AHCC increases natural killer cell activity in cancer patients and even boosts killer T cells, i.e. T lymphocytes and cytokines (interferon, IL-12, TNF-alpha).
– Today, AHCC is widely used in more than 700 clinics and hospitals in Japan and China alone to protect a patient’s immune system in addition to chemotherapy or radiation.
AHCC stimulates cell-mediated immunity:
– Based on human and laboratory experiments, AHCCs increase the number and activity of natural killer (NK) cells, dendritic cells and cytokines, so the body responds more effectively to infections and inhibits tumor growth. . The result was announced at the 45th Annual Conference of the American Society of Gynecological Oncologists in Tampa, Florida.
– AHCC stimulates cell-mediated immunity by activating white blood cells, especially natural killer cells and macrophages, which directly attack abnormal cells, virus-infected cells or external viral and bacterial pathogens that enter the body. come.
Studies in brief:
– AHCC and cancer.
– Fungal and bacterial infections.
– Viral infections – HPV.
– Immunological effects of AHCC in healthy volunteers.
– Improving the chances of recovery in patients with advanced liver cancer using AHCC treatment.
– Reduction of side effects during chemotherapy of cancer patients with AHCC.
AHCC and cancer:
According to a study published in the Journal of Hepatology, 113 patients underwent AHCC during postoperative liver cancer after surgery, compared with a control group of 156.
The results showed that the recurrence of the malignancy was significantly lower (34% compared to 66% in the control group) and the survival rate of the patients was significantly higher (80% compared to 52% in the control group).
The margin of error remained low because the results were carefully recorded and patients were closely monitored. Photographic documentation of tumors and lesions was obtained during the surgeries.
Fungal and Bacterial Infections:
Simulated by studying mice with reduced immunity, chemotherapeutic agents reduce the body’s resistance and white blood cell count. The protective effect of AHCC has been studied in Pseudomonas aeruginosa infection. AHCC was administered to mice by injection. Mice in the control group died within 3 days. In the AHCC-treated group, 6 of 8 mice were alive even on day 14. The lifespan of mice treated with high levels of AHCC was significantly increased.
The conclusion is that AHCC is able to protect immunocompromised patients from fungal and bacterial superinfections.
Viral Infections – HPV:
Human papillomavirus (HPV) is a common, highly contagious pathogen that attacks the skin and mucous membranes of the body, including the cervix, mouth, and pharynx. More than three-quarters of women get the virus in their lifetime.
However, researchers at the University of Texas Medical Center have shown that combined active hexose compounds (AHCC) extracted from the siitake fungus can help prevent the development of HPV-related tumors.
In their mouse experiment, the combined active hexose compounds killed the human papillomavirus within 90 days and also reduced the growth rate of cervical cancer.
Oxidative stress can cause tissue damage by forming reactive oxygen radicals and accelerate the aging process.
An animal experiment at Dokkyo University School of Medicine shows that AHCC protected mice from oxidative injury created with a strong oxidant, ferric nitrilotriacetate (FNT). This chemical can cause cancer and damage certain internal organs, especially the kidneys and liver.
8-OHdG, a marker of oxidative stress detectable in urine after pretreatment with AHCC, remained significantly low. This marker shows the degree of oxidative stress on DNA, indicates a risk factor for cancer, atherosclerosis, and diabetes, the amount of creatinine, the degree of kidney and liver damage, and the low rate of thyroid apoptosis, an indicator of immune deficiency.
These results demonstrate a high level and extensive protection against oxidative stress.
Immunological effects of AHCC in healthy volunteers:
– The aim of this study was to assess the effect of AHCC intake on immune responses in healthy volunteers by examining the number and function of circulating dendritic cells (DCs). A double-blind, placebo-controlled study was performed.
– 21 healthy volunteers were randomized to receive placebo or AHCC at a daily dose of 3.0 g for 4 weeks. Circulating DC cell counts and natural killer (NK) cell activity and mitogenic proliferative response of T lymphocytes were measured.
– In the AHCC group, total DC values were significantly higher after AHCC intake, from baseline and from control subjects. In the AHCC group, the number of natural killer cells was significantly increased compared to controls.
– All these results suggest that the use of AHCC may play a significant and specific role in immunity.
Improving the chances of recovery in patients with advanced liver cancer using AHCC treatment:
The majority of patients with liver cancer are diagnosed when they are no longer suitable for liver transplantation. The overall survival rate remains unsatisfactory.
– The study was performed in 44 patients with histologically confirmed liver cancer. 34 patients received AHCC supportive treatment orally and 10 patients received placebo.
– Clinical and immunological parameters related to survival time, quality of life, liver function, cellular immunity, and patient condition were determined. After 3 months of AHCC treatment, survival and overall mental and physical status were significantly prolonged in the AHCC-treated group compared to the control group.
– It can be stated that AHCC intake can prolong the survival and improve the prognosis of patients with advanced liver cancer and delay the gradual deterioration of their physiological condition.
Reduction of side effects during chemotherapy of cancer patients with AHCC:
– Cancer patients are sometimes forced to discontinue chemotherapy or to be excluded from a clinical trial due to adverse effects such as gastrointestinal disorders and bone marrow dysfunction.
– The aim of the study was to evaluate the efficacy of AHCC on the adverse effects of chemotherapy and on quality of life in cancer patients.
– 24 cancer patients received the first cycle of chemotherapy without AHCC and then the second cycle with AHCC. During chemotherapy, adverse effects were assessed by weekly blood tests, a questionnaire, and evaluation of the levels of herpesvirus type 6 (HHV-6) DNA in saliva.
– HHV-6 DNA levels increased significantly after chemotherapy. Interestingly, AHCC administration significantly reduced HHV-6 levels in saliva during chemotherapy and improved not only questionnaire scores but also hematotoxicity and hepatotoxicity.
– The results show that AHCC may have a beneficial effect on the adverse effects associated with chemotherapy and on cancer patients who have undergone chemotherapy.
Alpha-glucans and Beta-glucans:
– Polysaccharides make up 40% of AHCC. These include beta-glucans and acetylated alpha-glucans.
– Glucans are polysaccharides that have an immunostimulatory effect. Due to its low molecular weight (around 5,000 daltons), acetylated alpha-glucan is more easily absorbed compared to higher molecular weight beta-glucan (200 kDa).
– β-glucans (Beta-glucans) are a group of β-D-glucose polysaccharides that occur naturally in the cell walls of cereals, bacteria and fungi and have significantly different physicochemical properties depending on the source.
– In general, β-glucans form a linear backbone with 1 to 3 β-glycoside bonds, but vary with molecular weight, solubility, viscosity, branching structure, and gelling properties, causing various physiological effects in animals.
– With a dietary intake of at least 3 g per day, zabrost β-glucan lowers blood LDL cholesterol levels and may reduce the risk of cardiovascular disease.
– β-glucans are used as texturizing agents in various food and cosmetic products as well as soluble fiber supplements, but can be problematic during brewing.
– Antithrombotic effect.
– Reduces blood viscosity.
– Promotes the efficiency of the immune system.
– Limits cholesterol deposition.
– Promotes the efficiency of the immune system.
– AHCC is produced, inter alia, by growing mycelium of basidiomycetes (fungal filament pieces) in 45-60 days in large containers.
– Many different types of mycelium are cultured at the beginning to form a colony (a large mycelium mass).
– When the culture process is completed, the product undergoes an enzyme reaction, is sterilized, concentrated and freeze-dried.
What are Flavonoids?
The name flavonoids refers to a group of compounds whose members have a similar chemical backbone and are found mainly in the peel and seeds of fruits and vegetables. Flavonoids are produced by plants for their own protection.
It is important to know about the physiological effects of flavonoids, that they act mainly in the digestive and circulatory systems and are absorbed in the intestinal tract. It neutralizes free radicals, ie they have an antioxidant effect and reduce the risk of atherosclerosis. They inhibit thrombosis, increase the elasticity of blood vessel walls. They have an effect on sootome lesions (mutagenesis) and the process of developing malignancies (carcinogenesis).
They lower LDL (“bad” cholesterol) and blood fat (serum tridlyceride) levels. They have a liver and sunscreen effect. They are anti-inflammatory, prevent long-term complications of diabetes mellitus, and have antiviral, antibacterial effects.
Watch a short introductory video about flavonoids:
How long have we known about Flavonoids?
In 1936, Albert Szent-Györgyi and István Rusznyák were the first to show that two flavonoids (rutin, naringenin) from citrus fruits reduce the fragility and permeability of capillaries, which is why rutin was first named vitamin P. Since then, science has isolated thousands of similar compounds.
What are Flavonoids good for?
Flavonoids increase the body’s antioxidant capacity, which can reduce the cell-destroying effects of free radicals. They support the optimal operation of the defense system.
Red grapes can help the vascular system to function optimally, improve circulation. Through its antioxidant properties, it can help protect cells from the destructive effects of free radicals.
Shiitake mushroom (Lentinula edodes extract) extract, AHCC extract (glucans 50%), Sealing wax mushroom (Ganoderma lucidum extract) extract, Woolly ink (Coprinus comatus) meal, Flavin7 Bioflavonoid complex, red grape seed husk drying, blackberry seed husk drying, black cherry husk drying, blackcurrant seed husk drying, redcurrant seed husk drying, plum husk drying, apple husk drying), capsule coating: gelatin, colorant: titanium dioxide.
Active ingredient in daily dose:
|Woolly squid (Coprinus comatus) meal||100 mg|
– of which glucans
|Shiitake mushroom (Lentinula edodes extract) extract (30%)|
– of which polysaccharides
|Sealing wax fungus (Ganoderma lucidum extract) extract (30%)|
– of which polysaccharides
– of which flavonoids
– 3×1 capsules / day and 3×2 capsules / day as needed and needed.
– 120 capsules.