Fungi : Contrary to popular belief, fungi do not belong to plants, but form a distinct group of living beings on an equal footing with plants and animals. The number of known fungal species on Earth is around one hundred thousand, but it is assumed that as yet unknown species can account for three to four times that.
Fungi synthesize a number of biologically active metabolites, some of which are specifically beneficial to human health. Just as we know herbs, so do healing fungi.
Several groups of fungi produce medicinal substances. Of these, antibiotic-producing microscopic molds (e.g., penicillium) are more widely known. Very important drugs are produced from the plant parasitic plant parasitic rye (Claviceps purpurea), which contains more than a hundred biologically active compounds.
The effects of
medicinal fungi on the human body are divided into four major groups: – Antibiotic-producing large fungi.
– Fungi for circulatory diseases.
– Fungi acting against immunostimulatory vascular cancer.
– Cholesterol-lowering fungi.
The fungus as a human food:
The amino acid composition of fungal proteins is nutritionally favorable (better than that of plants).
– Fungi contain all 20 protein-forming amino acids, including essential amino acids (which the body cannot produce).
– Their high fiber content increases intestinal motility.
– Significant source of vitamins B and D and potassium and phosphorus – medicinal and immune-boosting substances.
Shiitake Mushroom (Lentinus edodes):
May stimulate the nervous system and immune system.
– Slightly garlic flavored.
– Many experiments have been performed with its excellent active ingredients.
– It is known all over the world, it is the most grown after the mushroom.
– A close relative, the red fungus, also grows with us, it contains the same active ingredients.
Nowadays, more than 20 tons of mushrooms are grown in Hungary every year, but only a fraction of this goes to the Hungarian markets due to its high price and unknowns, and the rest is exported. Its health-protective effect lies primarily in its carbohydrate composition. A number of complex carbohydrates, polysaccharides, including lentinane, have been shown to inhibit the growth of bacteria and viruses and even have an anti-tumor effect by strengthening the immune system. The researchers explain this by the fact that lentinan produces biologically active substances that stimulate the body’s immune system and increase the activity of phagocytes in the blood. This also explains the allergy and anti-inflammatory effect of the fungus.
Today, in many foreign hospitals, doctors administer shiitake extract to the patient at the same time as chemotherapy for cancer to reduce the harmful side effects of strong chemicals on healthy tissues and the immune system. Regular consumption of the fungus (due to its erythadine content) significantly lowers blood cholesterol levels, thus protecting against the development of high blood pressure and atherosclerosis, and also plays a role in preventing cerebral hemorrhage. In Japan, Tohoku University found that shiitake mushrooms increase insulin production, thereby lowering blood sugar levels, so consuming the mushroom is also recommended for diabetics. The detoxifying effect of shiitake mushrooms (due to their thioprolin content) should also be highlighted, as it binds carcinogenic nitrites used in the preservation of foods.Shiitake also plays a significant role in the macrobiotic diet, mainly known for its mucolytic and dehydrating effects due to the consumption of dairy products and animal fats.
Research has shown:
– Its antiviral effect against influenza A, mumps, herpes, HIV, Epstein-Barr and hepatitis B viruses.
– Antibacterial and antifungal effect.
– Immunostimulatory effect.
– Indirect antitumor and prolongs the life of cancer patients.
– Antioxidant, liver protector and relieves inflammatory processes in the liver.
– It lowers LDL cholesterol and increases HDL cholesterol, slowing the process of atherosclerosis. In the 1960s, Japanese researchers demonstrated that a diet supplemented with 5% shii-take mushrooms reduced blood cholesterol levels as well as triglyceride levels by 24-45%.
– Blood sugar lowering.
– General strengthening and invigorating effect.
– AHCC (Active Hexose Correlated Compound), a combined active hexose compound is a chemical obtained from the yeast cell wall of the shiitake (Lentinellus edodes) fungus and other fungi fermented on rice bran.
– Developed for the treatment of lifestyle diseases. Developed by Toshihiko Okamoto, a professor of pharmacology at Tokyo University, in collaboration with Amino Up Chemical Co. in Sapporo, Japan.
Why is AHCC more effective?
– In their natural state, the substances of medicinal fungi are less able to be absorbed. Their biologically active ingredients, polysaccharides, are too large to easily pass through the miniature gaps of the gastrointestinal tract.
– Due to its low molecular weight, acetylated alpha-glucan is more easily absorbed compared to higher molecular weight beta-glucan.
– The acetylated alpha-glucan, unique in AHCC, is formed during the cultivation of fungal mycelium. Glucans are polysaccharides that have an immunostimulatory effect.
Developed to treat lifestyle diseases:
– AHCC was first used to reduce high blood pressure, and then researchers at the University of Tokyo found that AHCC increases natural killer cell activity in cancer patients and even boosts killer T cells, i.e. T lymphocytes and cytokines (interferon, IL-12, TNF-alpha).
– Today, AHCC is widely used in more than 700 clinics and hospitals in Japan and China alone to protect a patient’s immune system in addition to chemotherapy or radiation.
AHCC stimulates cell-mediated immunity:
– Based on human and laboratory experiments, AHCCs increase the number and activity of natural killer (NK) cells, dendritic cells and cytokines, so the body responds more effectively to infections and inhibits tumor growth. . The result was announced at the 45th Annual Conference of the American Society of Gynecological Oncologists in Tampa, Florida.
– AHCC stimulates cell-mediated immunity by activating white blood cells, especially natural killer cells and macrophages, which directly attack abnormal cells, virus-infected cells or external viral and bacterial pathogens that enter the body. come.
Studies in brief:
– AHCC and cancer.
– Fungal and bacterial infections.
– Viral infections – HPV.
– Immunological effects of AHCC in healthy volunteers.
– Improving the chances of recovery in patients with advanced liver cancer using AHCC treatment.
– Reduction of side effects during chemotherapy of cancer patients with AHCC.
AHCC and cancer:
According to a study published in the Journal of Hepatology, 113 patients underwent AHCC during postoperative liver cancer after surgery, compared with a control group of 156.
The results showed that the recurrence of the malignancy was significantly lower (34% compared to 66% in the control group) and the survival rate of the patients was significantly higher (80% compared to 52% in the control group).
The margin of error remained low because the results were carefully recorded and patients were closely monitored. Photographic documentation of tumors and lesions was obtained during the surgeries.
Fungal and Bacterial Infections:
Simulated by studying mice with reduced immunity, chemotherapeutic agents reduce the body’s resistance and white blood cell count. The protective effect of AHCC has been studied in Pseudomonas aeruginosa infection. AHCC was administered to mice by injection. Mice in the control group died within 3 days. In the AHCC-treated group, 6 of 8 mice were alive even on day 14. The lifespan of mice treated with high levels of AHCC was significantly increased.
The conclusion is that AHCC is able to protect immunocompromised patients from fungal and bacterial superinfections.
Viral Infections – HPV:
Human papillomavirus (HPV) is a common, highly contagious pathogen that attacks the skin and mucous membranes of the body, including the cervix, mouth, and pharynx. More than three-quarters of women get the virus in their lifetime.
However, researchers at the University of Texas Medical Center have shown that combined active hexose compounds (AHCC) extracted from the siitake fungus can help prevent the development of HPV-related tumors.
In their mouse experiment, the combined active hexose compounds killed the human papillomavirus within 90 days and also reduced the growth rate of cervical cancer.
Oxidative stress can cause tissue damage by forming reactive oxygen radicals and accelerate the aging process.
An animal experiment at Dokkyo University School of Medicine shows that AHCC protected mice from oxidative injury created with a strong oxidant, ferric nitrilotriacetate (FNT). This chemical can cause cancer and damage certain internal organs, especially the kidneys and liver.
8-OHdG, a marker of oxidative stress detectable in urine after pretreatment with AHCC, remained significantly low. This marker shows the degree of oxidative stress on DNA, indicates a risk factor for cancer, atherosclerosis, and diabetes, the amount of creatinine, the degree of kidney and liver damage, and the low rate of thyroid apoptosis, an indicator of immune deficiency.
These results demonstrate a high level and extensive protection against oxidative stress.
Immunological effects of AHCC in healthy volunteers:
– The aim of this study was to assess the effect of AHCC intake on immune responses in healthy volunteers by examining the number and function of circulating dendritic cells (DCs). A double-blind, placebo-controlled study was performed.
– 21 healthy volunteers were randomized to receive placebo or AHCC at a daily dose of 3.0 g for 4 weeks. Circulating DC cell counts and natural killer (NK) cell activity and mitogenic proliferative response of T lymphocytes were measured.
– In the AHCC group, total DC values were significantly higher after AHCC intake, from baseline and from control subjects. In the AHCC group, the number of natural killer cells was significantly increased compared to controls.
– All these results suggest that the use of AHCC may play a significant and specific role in immunity.
Improving the chances of recovery in patients with advanced liver cancer using AHCC treatment:
The majority of patients with liver cancer are diagnosed when they are no longer suitable for liver transplantation. The overall survival rate remains unsatisfactory.
– The study was performed in 44 patients with histologically confirmed liver cancer. 34 patients received AHCC supportive treatment orally and 10 patients received placebo.
– Clinical and immunological parameters related to survival time, quality of life, liver function, cellular immunity, and patient condition were determined. After 3 months of AHCC treatment, survival and overall mental and physical status were significantly prolonged in the AHCC-treated group compared to the control group.
– It can be stated that AHCC intake can prolong the survival and improve the prognosis of patients with advanced liver cancer and delay the gradual deterioration of their physiological condition.
Reduction of side effects during chemotherapy of cancer patients with AHCC:
– Cancer patients are sometimes forced to discontinue chemotherapy or to be excluded from a clinical trial due to adverse effects such as gastrointestinal disorders and bone marrow dysfunction.
– The aim of the study was to evaluate the efficacy of AHCC on the adverse effects of chemotherapy and on quality of life in cancer patients.
– 24 cancer patients received the first cycle of chemotherapy without AHCC and then the second cycle with AHCC. During chemotherapy, adverse effects were assessed by weekly blood tests, a questionnaire, and evaluation of the levels of herpesvirus type 6 (HHV-6) DNA in saliva.
– HHV-6 DNA levels increased significantly after chemotherapy. Interestingly, AHCC administration significantly reduced HHV-6 levels in saliva during chemotherapy and improved not only questionnaire scores but also hematotoxicity and hepatotoxicity.
– The results show that AHCC may have a beneficial effect on the adverse effects associated with chemotherapy and on cancer patients who have undergone chemotherapy.
Alpha-glucans and Beta-glucans:
– Polysaccharides make up 40% of AHCC. These include beta-glucans and acetylated alpha-glucans.
– Glucans are polysaccharides that have an immunostimulatory effect. Due to its low molecular weight (around 5,000 daltons), acetylated alpha-glucan is more easily absorbed compared to higher molecular weight beta-glucan (200 kDa).
– β-glucans (Beta-glucans) are a group of β-D-glucose polysaccharides that occur naturally in the cell walls of cereals, bacteria and fungi and have significantly different physicochemical properties depending on the source.
– In general, β-glucans form a linear backbone with 1 to 3 β-glycoside bonds, but vary with molecular weight, solubility, viscosity, branching structure, and gelling properties, causing various physiological effects in animals.
– With a dietary intake of at least 3 g per day, zabrost β-glucan lowers blood LDL cholesterol levels and may reduce the risk of cardiovascular disease.
– β-glucans are used as texturizing agents in various food and cosmetic products as well as soluble fiber supplements, but can be problematic during brewing.
– Antithrombotic effect.
– Reduces blood viscosity.
– Promotes the efficiency of the immune system.
– Limits cholesterol deposition.
– Promotes the efficiency of the immune system.
– AHCC is produced, inter alia, by growing mycelium of basidiomycetes (fungal filament pieces) in 45-60 days in large containers.
– Many different types of mycelium are grown at the beginning to form a colony (a large mycelial mass).
– When the culture process is completed, the product undergoes an enzyme reaction, is sterilized, concentrated and freeze-dried.
Shiitake Mushroom (Lentinus edodes) Extract, Flavin7 Bioflavonoid complex (red grape seed husk drying, sorghum seed husk drying, blackberry seed husk drying, black cherry husk drying, blackcurrant seed husk drying, redcurrant husk drying, redcurrant seed husk) , apple peel drying), Yeast extract (glucans 30%), AHCC extract (glucans 50%), capsule coating: gelatin, dye: titanium dioxide.
Each capsule can be pulled apart and the active ingredient in it can be consumed without it!
Active ingredient in daily dose:
|1 capsule||3 capsules|
(Lentinus edodes) extracts (30%)
|300 mg||900 mg|
|AHCC extract (50%) and
yeast extract (30%)
– of which glucans
– of which flavonoids
– 3×1 capsules / day and 3×2 capsules / day as needed and needed.
– 120 capsules.