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Double Zinc Exc-Inc capsule (2x30pcs)

Double Zinc Exc-Inc capsule (2x30pcs)

13,13

Complex immune boost!
Quercetin has a potent immune-boosting and broad-spectrum antiviral effect.
It has three main mechanisms of action:
– Inhibition of the cell’s ability to infect cells.
– Inhibition of replication of already infected cells.
– Reduction of antiviral drug resistance in infected cells.
Zinc maintains the integrity of cells, essential for protein synthesis, DNA production. It is the most important trace element in the control of infections.
The acetylated alpha-glucan, uniquely found in AHCC, is formed during the cultivation of fungal mycelium and, due to its low molecular weight, is more easily absorbed compared to higher molecular weight beta-glucan. Glucans are polysaccharides that have an immunostimulatory effect.

Description

Quercetin:
– Quercetin derivatives have been shown to provide broad-spectrum protection against a wide range of viruses.
– Quercetin has a strong immune-boosting and broad-spectrum antiviral effect. It inhibits the release of pro-inflammatory cytokines, which may be beneficial as severe infection and subsequent death are due to storm activity of the cytokines.
– Quercetin also stabilizes mast cells and has a direct regulatory effect on the basic functional properties of immune cells, either by downregulation or by suppressing many inflammations and functions.
– Quercetin in red wine is one of the strongest known antitumor substances besides resveratrol, which directly inhibits the division and proliferation of malignant cells.
– Prevents atherosclerosis.
– Antihypertensive effect.
– Inhibitory effect on colon and rectal tumor cell lines.
– Inhibitor of bacterial growth (Helicobacter pylori).

How does Quercetin inhibit viral infection?
One of the most studied properties of quercetin is its antiviral ability, which is attributed to three main mechanisms of action:
– Inhibition of the cell’s ability to infect cells.
– Inhibition of replication of already infected cells.
– Reduction of antiviral drug resistance in infected cells.

 

Studies – Details of Quercetin:

Research funded by the U.S. Department of Defense, published in 2007, has shown that quercetin reduces the risk of viral diseases. Which can otherwise undermine the effectiveness of the immune system and make it more prone to infections due to extreme physical stress.

Another DARPA-funded study published in 2008 by the U.S. Department of Defense’s research department reported that quercetin-treated animals were infected with the highly pathogenic H1N1 influenza virus. The treatment group had significantly lower morbidity and mortality than the placebo-treated group.

Other studies have confirmed the efficacy of quercetin against a wide range of viruses.

It has gained a controversial reputation since its discovery and in related laboratory tests, as it became known first as a mutagen and then as an effective anticancer compound. Quercetin in red wine is one of the strongest known antitumor substances besides resveratrol, which directly inhibits the division and proliferation of malignant cells.
It exerts this by stimulating apoptosis. Modification and inhibition of the activity of various enzymes.

Resveratrol and quercetin are effective in inhibiting the growth and proliferation of oral epithelial carcinomas.
Apigenin and quercetin inhibit the growth of melanoma. Quercetin inhibits P21-RAS expression in a primary human colon and rectal cell line.

Zinc:
– Controls and controls metabolic processes in the body, a component of insulin.
– Maintains cell integrity, essential for protein synthesis, DNA production.
– The most important trace element in the fight against infections, as well as important for the skin, hair and nails. The organization needs a constant supply.
– Zinc is an important component of enzymes that, together with flavonoids, protect the body against the harmful effects of free radicals. AHCC:
– AHCC (Active Hexose Correlated Compound), a combined active hexose compound is a chemical obtained from the yeast cell wall of the shiitake (Lentinellus edodes) fungus and other fungi fermented on rice bran.
– Developed for the treatment of lifestyle diseases. Developed by Toshihiko Okamoto, a professor of pharmacology at Tokyo University, in collaboration with Amino Up Chemical Co. in Sapporo, Japan.

Why is AHCC more effective?
– In their natural state, the substances of medicinal fungi are less able to be absorbed. Their biologically active ingredients, polysaccharides, are too large to easily pass through the miniature gaps of the gastrointestinal tract.
– Due to its low molecular weight, acetylated alpha-glucan is more easily absorbed compared to higher molecular weight beta-glucan.
– The acetylated alpha-glucan, unique in AHCC, is formed during the cultivation of fungal mycelium. Glucans are polysaccharides that have an immunostimulatory effect.

Developed to treat lifestyle diseases:
– AHCC was first used to reduce high blood pressure, and then researchers at the University of Tokyo found that AHCC increases natural killer cell activity in cancer patients and even boosts killer T cells, i.e. T lymphocytes and cytokines (interferon, IL-12, TNF-alpha).
– Today, AHCC is widely used in more than 700 clinics and hospitals in Japan and China alone to protect a patient’s immune system in addition to chemotherapy or radiation.

AHCC stimulates cell-mediated immunity:
– Based on human and laboratory experiments, AHCCs increase the number and activity of natural killer (NK) cells, dendritic cells, and cytokines, so the body responds more effectively to infections and inhibits tumor growth. . The result was announced at the 45th Annual Conference of the American Society of Gynecological Oncologists in Tampa, Florida.
– AHCC stimulates cell-mediated immunity by activating white blood cells, especially natural killer cells and macrophages, which directly attack abnormal cells, virus-infected cells or external viral and bacterial pathogens that enter the body. come.

Studies in brief:
– AHCC and cancer.
– Fungal and bacterial infections.
– Viral infections – HPV.
– Prevention.
– Immunological effects of AHCC in healthy volunteers.
– Improving the chances of recovery in patients with advanced liver cancer using AHCC treatment.
– Reduction of side effects during chemotherapy of cancer patients with AHCC.

Studies – AHCC details:

AHCC and cancer:
According to a study published in the Journal of Hepatology, 113 patients underwent AHCC during postoperative liver cancer after surgery, compared with a control group of 156.
The results showed that the recurrence of the malignancy was significantly lower (34% compared to 66% in the control group) and the survival rate of the patients was significantly higher (80% compared to 52% in the control group).
The margin of error remained low because the results were carefully recorded and patients were closely monitored. Photographic documentation of tumors and lesions was obtained during the surgeries.

Fungal and Bacterial Infections:
Simulated by studying mice with reduced immunity, chemotherapeutic agents reduce the body’s resistance and white blood cell count. The protective effect of AHCC has been studied in Pseudomonas aeruginosa infection. AHCC was administered to mice by injection. Mice in the control group died within 3 days. In the AHCC-treated group, 6 of 8 mice were alive even on day 14. The lifespan of mice treated with high levels of AHCC was significantly increased.
The conclusion is that AHCC is able to protect immunocompromised patients from fungal and bacterial superinfections.

Viral Infections – HPV:
Human papillomavirus (HPV) is a common, highly infectious pathogen that attacks the skin and mucous membranes of the body, including the cervix, mouth, and pharynx. More than three-quarters of women get the virus in their lifetime.
However, researchers at the University of Texas Medical Center have shown that combined active hexose compounds (AHCC) extracted from the siitake fungus can help prevent the development of HPV-associated tumors.
In their mouse experiment, the combined active hexose compounds killed the human papillomavirus within 90 days and also reduced the growth rate of cervical cancer.

Prevention:
Oxidative stress can cause tissue damage by forming reactive oxygen radicals and accelerate the aging process.
An animal experiment at Dokkyo University School of Medicine shows that AHCC protected mice from oxidative injury created with a strong oxidant, ferric nitrilotriacetate (FNT). This chemical can cause cancer and damage certain internal organs, especially the kidneys and liver.
8-OHdG, a marker of oxidative stress detectable in urine as a result of AHCC pretreatment, remained significantly low. This marker shows the degree of oxidative stress on DNA, indicates a risk factor for cancer, atherosclerosis, and diabetes, the amount of creatinine, the degree of kidney and liver damage, and the low rate of thyroid apoptosis, which is an indicator of immune deficiency.
These results demonstrate a high level and extensive protection against oxidative stress.

Immunological effects of AHCC in healthy volunteers:
– The aim of this study was to assess the effect of AHCC intake on immune responses in healthy volunteers by examining the number and function of circulating dendritic cells (DCs). A double-blind, placebo-controlled study was performed.
– 21 healthy volunteers were randomized to receive placebo or AHCC at a daily dose of 3.0 g for 4 weeks. The number of circulating DCs and the activity of natural killer (NK) cells and the mitogenic proliferative response of T lymphocytes were measured.
– In the AHCC group, total DC values ​​were significantly higher after AHCC intake, from baseline and from control subjects. In the AHCC group, the number of natural killer cells was significantly increased compared to controls.
– All these results suggest that the use of AHCC may play a significant and specific role in immunity.

Improving the chances of recovery in patients with advanced liver cancer using AHCC treatment:
The majority of patients with liver cancer are diagnosed when they are no longer suitable for liver transplantation. The overall survival rate remains unsatisfactory.
– The study was performed in 44 patients with histologically confirmed liver cancer. 34 patients received AHCC supportive treatment orally and 10 patients received placebo.
– Clinical and immunological parameters related to survival time, quality of life, liver function, cellular immunity, and patient condition were determined. After 3 months of AHCC treatment, survival and overall mental and physical status were significantly prolonged in the AHCC-treated group compared with the control group.
– It can be stated that AHCC intake can prolong the survival and improve the prognosis of patients with advanced liver cancer and delay the gradual deterioration of their physiological condition.

Reduction of side effects during chemotherapy of cancer patients with AHCC:
– Cancer patients are sometimes forced to discontinue chemotherapy or to be excluded from a clinical trial due to adverse effects such as gastrointestinal disorders and bone marrow dysfunction.
– The aim of the study was to evaluate the efficacy of AHCC on the adverse effects of chemotherapy and on quality of life in cancer patients.
– 24 cancer patients received the first cycle of chemotherapy without AHCC and then the second cycle with AHCC. During chemotherapy, adverse effects were assessed by weekly blood tests, a questionnaire, and evaluation of the levels of herpesvirus type 6 (HHV-6) DNA in saliva.
– HHV-6 DNA levels increased significantly after chemotherapy. Interestingly, AHCC administration significantly reduced HHV-6 levels in saliva during chemotherapy and improved not only questionnaire scores but also hematotoxicity and hepatotoxicity.
– The results show that AHCC may have a beneficial effect on the adverse effects associated with chemotherapy and on cancer patients who have undergone chemotherapy.

Alpha-glucans and Beta-glucans:
– Polysaccharides make up 40% of AHCC. These include beta-glucans and acetylated alpha-glucans.
– Glucans are polysaccharides that have an immunostimulatory effect. Due to its low molecular weight (around 5,000 daltons), acetylated alpha-glucan is more easily absorbed compared to higher molecular weight beta-glucan (200 kDa).

– β-glucans (Beta-glucans) are a group of β-D-glucose polysaccharides that occur naturally in the cell walls of cereals, bacteria and fungi and have significantly different physicochemical properties depending on the source.
– In general, β-glucans form a linear backbone with 1 to 3 β-glycoside bonds, but vary with molecular weight, solubility, viscosity, branching structure, and gelling properties, causing various physiological effects in animals.
– With a dietary intake of at least 3 g per day, zabrost β-glucan lowers blood LDL cholesterol levels and may reduce the risk of cardiovascular disease.
– β-glucans are used as texturizing agents in various food and cosmetic products as well as soluble fiber supplements, but can be problematic during brewing.

Alpha-glucan:
– Antithrombotic effect.
– Reduces blood viscosity.
– Promotes the efficiency of the immune system.

Beta-glucan:
– Limits cholesterol deposition.
– Promotes the efficiency of the immune system.

Manufacturing process:
– AHCC is produced, inter alia, by growing mycelium of basidiomycetes (fungal filament pieces) in 45-60 days in large containers.
– Many different types of mycelium are cultured at the beginning to form a colony (a large mycelium mass).

– When the culture process is complete, the product undergoes an enzyme reaction, is sterilized, concentrated and freeze-dried.

Double Zin – EXC:
Ingredients:
Flavin7 Bioflavonoid complex (red grape seed husk drying, sorghum seed husk drying, blackberry seed husk drying, black cherry husk drying, blackcurrant seed husk drying, redcurrant husk husk, husk husk husk drying apple peel drying), yeast extract (glucan content 30%), zinc acetate (zinc 30%), AHCC extract (glucan content 50%), capsule coating: gelatin, dye: titanium dioxide.
Each capsule can be pulled apart and the active ingredient in it can be consumed without it!

Active ingredient in daily dose:

1 capsule
Bioflavonoid complex
– of which polyphenol
– of which flavonoid
– of which resveratrol
387.5 mg
129.3 mg
90.52 mg
0.124 mg
AHCC extract (50%)
and yeast extract (30%)
– of which glucans
100 mg

30.4 mg

Zinc 10.5 mg * NRV 105%

* NRV:% of recommended daily intake for adults.

Double Zin – INC:
Ingredients:
Flavin7 Bioflavonoid complex (red grape seed husk drying, sorghum seed husk drying, blackberry seed husk drying, black cherry husk drying, blackcurrant seed husk drying, redcurrant husk husk drying, redcurrant husk husk drying apple peel dried), Sophora Japonica L. extract (Quercetin 98%), Zinc acetate (zinc 30%), capsule coating: gelatin, dye: titanium dioxide.
Each capsule can be pulled apart and the active ingredient in it can be consumed without it!

Active ingredient in daily dose:

1 capsule
Bioflavonoid complex
– of which polyphenol
– of which flavonoid
– of which quercetin
Resveratrol
340 mg
113.42 mg
79.42 mg
39.2 mg
0.108 mg
Zinc 10.5 mg * NRV 105%

* NRV:% of recommended daily intake for adults.

Recommended use:
– 1 Double Zinc EXC capsule / day in the morning, 1 Double Zinc INC capsule / day in the afternoon.

Packaging:
– 2 x 30 capsules.